Endocrine Abstracts

Objective: To investigate whether restoration of insulin secretion and long-term optimal glycemic control can be achieved by short-term liraglutide (a glucagon-like peptide-1 receptor agonist) therapy compared with basal insulin therapy in Japanese patients with type 2 diabetes.Research Design and Methods: Japanese subjects with type 2 diabetes had a short-term, 3 week course of basal insulin therapy (n=114) or liraglutide therapy (n=29) to...

Introduction: Bile acid binding resins (BABRs), anion exchange resins developed as medication for hypercholesterolemia, have been reported to improve glycemic control in patients and animal models with type 2 diabetes mellitus. Although the mechanism has not been clarified yet, we suspect that diverse factors including peripheral bile acid composition and incretins play significant roles in the effect. Besides BABRs, bile acids (BAs) administration has been recently reported t...